Fig. 8: Evolution of the innate transcriptomic signatures in PBMC samples after LASV challenge over time.
From: Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys
Gene expression heatmap of three gene sets: A antiviral response, B cytokine response, and C monocyte response. Each time point represents the mean of n = 3 independent samples. The color of the cell represents the average standardized (centered and scaled) gene expression and the intensity of standardized expression is given by the scale. Bottom: Boxplot representation of the standard average expression (Standard aver. expr.) of the genes for each time point in the three gene sets (central line, median; hinges, first and third quartiles; whiskers, largest or smallest value no further than 1.5 times the interquartile range from the hinge). Outlying data are plotted individually. Mean values for each time point were statistically compared to assess their difference using the non-parametric two-samples unpaired Wilcoxon test with the Benjamini–Hochberg correction for multiple testing. The red asterisks represent significant differences between groups for the same time point and the green asterisks represent significant differences between time points for the same group. Statistical significance: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.
