Fig. 4: The infectivity of BA.2.75 in hACE2-expressing hamsters.
From: Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates
hACE2-expressing Syrian hamsters (n = 4) were intranasally inoculated with 105 PFU in 30 μL of BA.2 (NCD1288), BA.5 (TY41-702), BA.2.75 (TY41-716), or B.1.617.2 (UW5250). Infected animals were euthanized at 5 dpi for virus titration (n = 4/group). Virus titers in the nasal turbinates and lungs were determined by performing plaque assays with Vero E6-TMPRSS2-T2A-ACE2 cells. Vertical bars show the mean ± s.e.m. Points indicate data from individual animals. The lower limit of detection is indicated by the horizontal dashed line. Data were analyzed by using a one-way ANOVA with Tukey’s multiple comparisons test (titers in the nasal turbinates) or the Kruskal–Wallis test followed by Dunn’s test (titers in the lungs). P values of <0.05 were considered statistically significant. Data are from one experiment.
