Fig. 5: Collateral drug sensitivities are retained within infected THP-1 macrophages. | Nature Communications

Fig. 5: Collateral drug sensitivities are retained within infected THP-1 macrophages.

From: The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis

Fig. 5

a–f The survival of intracellular M. tuberculosis drug-susceptible or resistant strains within THP-1 macrophages was determined after 3 days of exposure to compounds at or above the MIC. MICs are as follows; Q203 = 0.05 µM, BDQ = 0.2 µM, TAC = 0.5 µM, PA824 = 1 µM. CFUs/mL were used to determine M. tuberculosis survival. Results are presented as percentage (%) survival relative to the no compound DMSO control. Line graphs represent the mean of three biological replicates, with individual replicate values plotted for each concentration. Results are from a representative experiment (n = 2 independent experiments).

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