Table 1 Compounds used in this study
Antibiotic | Abbreviation | Target | Liquid MIC against M. tuberculosis mc26206 susceptible parent strain (µM) |
|---|---|---|---|
Rifampicin | RIF | Transcription | 0.1 |
Fidaxomicin | FIX | Transcription | 4 |
Linezolid | LZD | Translation | 3 |
Kanamycin | KAN | Translation | 4 |
Streptomycin | STRP | Translation | 0.15 |
Capreomycin | CAP | Translation | 1.1 |
Levofloxacin | LEV | DNA gyrase | 0.8 |
Bedaquiline | BDQ | Bioenergetics | 1 |
Clofazimine | CFZ | Bioenergetics | 0.5 |
Q203 | Q203 | Bioenergetics | 0.01 |
TB-47 | TB47 | Bioenergetics | 0.003 |
Pretomanid | PA824 | Bioenergetics/cell wall | 0.8 |
Isoniazid | INH | Cell wall | 0.5 |
Ethionamide | ETH | Cell wall | 10 |
Ethambutol | EMB | Cell wall | 3 |
PBTZ-169 | PBTZ | Cell wall | 0.001 |
AZ7371 | AZ7 | Cell wall | 1 |
SQ109 | SQ109 | Cell wall | 0.8 |
Thioacetazone | TAC | Cell wall | 4 |
Thiocarlide | TCL | Cell wall | 5 |
Thiophene-2 | THP | Cell wall | 1.5 |
Compound-1 (Molecule #429) | CPD1 | Cell wall | 0.1 |
Tunicamycin | TUN | Cell wall | 1.5 |
Nitrofurantoin | NFT | Undefined | 50 |
