Table 2 Drug-resistant M. tuberculosis mc26206 strains generated and used in this study
Resistant mutant | Isolating antibiotic | Isolating concentration (µM) |
|---|---|---|
RIF-1 | Rifampicin | 0.12 |
RIF-11 | 0.4 | |
RIF-21 | 1.2 | |
FIX-1 | Fidaxomicin | 30 |
LEV-1 | Levofloxacin | 1.2 |
LEV-2 | 1.2 | |
LEV-11 | 4 | |
LZD-1 | Linezolid | 4.5 |
LZD-2 | 15 | |
LZD-3 | 4.5 | |
KAN-1 | Kanamycin | 6 |
KAN-32 | 60 | |
STRP-2 | Streptomycin | 0.18 |
STRP-8 | 0.6 | |
STRP-20 | 1.8 | |
CAP-1 | Capreomycin | 3 |
CAP-10 | 10 | |
CAP-12 | 10 | |
PA824-8 | Pretomanid | 1.5 |
PA824-21 | 5 | |
PA824-41 | 15 | |
CFZ-1 | Clofazimine | 0.18 |
CFZ-3 | 0.18 | |
CFZ-6 | 0.18 | |
BDQ-2 | Bedaquiline | 2.7 |
BDQ-14 | 2.7 | |
TB47-42 | TB47 | 0.15 |
Q203-1 | Q203 | 0.06 |
Q203-13 | 0.2 | |
Q203-18 | 0.6 | |
AZ7-11 | AZ7371 | 24 |
PBTZ-1 | PBTZ-169 | 0.0015 |
PBTZ-2 | 0.0015 | |
INH-1 | Isoniazid | 0.3 |
INH-11 | 1 | |
INH-21 | 3 | |
ETH-1 | Ethionamide | 18 |
ETH-2 | 18 | |
ETH-6 | 18 | |
CPD-1-1 | CPD-1 | 1.5 |
CPD-1-3 | 1.5 | |
CPD-1-4 | 1.5 | |
THP-18 | Thiophene-2 | 3 |
THP-23 | 10 | |
TAC-1 | Thioacetazone | 3 |
TAC-16 | 10 | |
TAC-9 | 30 | |
TCL-1 | Thiocarlide | 50 |
