Fig. 2: Rs2238574 is a putative regulator of ARID3A expression. | Nature Communications

Fig. 2: Rs2238574 is a putative regulator of ARID3A expression.

From: A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression

Fig. 2

A UCSC Genome Browser views of chromatin state of 19p13.3. B Annotation of 20 candidate variants, the size and color of the triangle and/or circle is proportional to annotation data. C Association between rs2238574 genotypes and expression of ARID3A in EBV-transformed lymphocytes (CC, n = 30; CA, n = 80; AA, n = 37). Source data are derived from GTEx. D Three-dimensional chromatin interactions for the ARID3A locus in K562 cells. Source data are derived from 3D Genome Browser. E Luciferase reporter assay in HEK293T and K562 cells transfected with pGL3 plasmids containing rs2238574. Luciferase signals are normalized to Renilla signals. Data are representative of three independent experiments (Mean ± SD for quadruplicates). P values are calculated using unpaired two-tailed Student’s t test and indicated significant if *p < 0.05, **p < 0.01, or ***p < 0.001.

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