Fig. 2: The impacts of the Tobacco signature and DNA repair panel in DC.

a Heatmap showing the clinic information (top), correlated mutations (middle), and the SBS29 (Tobacco) signature contribution (bottom) in the D and G subtypes. The square is directed to a subset of patient samples of the D and G subtypes used for WES (n = 120). b Histogram showing the proportion of the samples with the habit of smoking in the Tobacco signature and DNA repair panel (two-sided Fisher’s exact test). c The dominant pathways in the Tobacco signature (top) and DNA repair panel (bottom). d Scatterplot showing the relationship between CYPs and aminoglycan catabolism at the protein level (two-sided Pearson’s correlation test). CYPs cytochromes P450 families. e Boxplot showing the TMB in the Tobacco signature and DNA repair panel (two-sided Wilcoxon signed-ranked test). Boxplot shows median (central line), upper and lower quartiles (box limits), and 1.5× interquartile range (whiskers). f Boxplot presenting the MSI score in the Tobacco signature and DNA repair panel (two-sided Wilcoxon signed-ranked test). MSI microsatellite instability. Boxplot shows median (central line), upper and lower quartiles (box limits), and 1.5× interquartile range (whiskers). g Heatmap depicting the represented proteins of the predominant pathways in the DNA repair panel. The square directs to a subset of patient samples in the D subtype used for WES. h A brief summary of the impacts of the Tobacco signature and DNA repair panel in DC. ****p < 1.0E−4, ***p < 1.0E−3, **p < 1.0E−2, * p < 0.05, ns. >0.05. Source data are provided as a Source data file.