Fig. 6: Circos plots showing stability patterns of five protein families.

a Circos plot displaying stability patterns of gene expression (outer circles) and gene score (inner circles) of human leukocyte antigen (HLA) protein family (member: HLA-A, HLA-B, HLA-C, HLA-DRA, HLA-DPA1, and HLA-DRB1). Samples with missing data or cell types with low cell counts are shown in grey. b–f Same as (a) but for (b) interferon regulatory factors (IRFs; member: IRF1, IRF2, IRF3, IRF4, IRF5, and IRF8), (c) interleukins (ILs; member: IL32, IL7R, IL10RA, IL2RB, IL1B and IL18), (d) chemokine (C-X-C motif) receptor/ligand (CXCR/L) protein family (member: CXCR4, CXCR5, CXCR6, CXCL8, CXCL10, and CXCL16), (e) Janus kinase (JAK) and signal transducer and activator of transcription (STAT) protein family (member: JAK1, JAK2, JAK3, STAT3, STAT4, and STAT6), and (f) tumor necrosis factor receptor superfamily (TNFRSF; member: TNFRSF1B, TNFRSF13C, TNFRSF10B, TNFRSF25, TNFRSF11A, and TNFRSF17). The CV of gene expression for each of n = 4 participants was calculated from pseudo-bulk intensities in the corresponding 6 independent peripheral blood mononuclear cell (PBMC) samples. The CV of gene score for each participant was based on either 6 (for n = 2 participants) or 3 (for other n = 2 participants) PBMC samples. Adobe Illustrator (version 27.1.1; https://www.adobe.com/products/illustrator.html) was used to arrange panels and edit text. Source data are provided as a Source Data file.