Fig. 2: Divergent and coincident expression patterns across ADAD, TREM2, and sAD by cell type.
From: Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
a Ridge plots showing the distribution of gene estimates extracted from the linear mixed models comparing control nuclei to ADAD, TREM2, and sAD nuclei within cell types. Only DEGs that passed multiple testing correction in at least one genetic group were considered. For inclusion, the gene must also have been nominally significant (p < 0.05) in the genetic group. The total number of genes is shown on the right tail. b Heatmaps of gene estimates from the same models emphasize the divergent and congruent expression patterns across genetic groups. The largest 500 estimates were selected per cell type and used to create full heatmaps (found in Supplement). “Modules” were manually created based on expression patterns and dendrogram groupings. The top 10% of genes from each module were extracted (order preserved) to produce the above heatmaps. “sAD sig.”, “TREM2 sig.”, and “ADAD sig.” depict the significance status of each gene for that group. “BH”: Benjamini–Hochberg p < 0.05, “Nominal”: p < 0.05, “NS”: not significant. Source data are provided as a Source Data file.
