Fig. 3: Mixed Th2/Th1 pulmonary responses in pre-patent (lung migratory) murine schistosome infection. | Nature Communications

Fig. 3: Mixed Th2/Th1 pulmonary responses in pre-patent (lung migratory) murine schistosome infection.

From: Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis

Fig. 3

A C57BL/6 mice were percutaneously infected with 40 or 180 cercariae, and samples taken at d21. B Inflammatory mediators in BAL were assessed via ELISA. C BAL cell isolates were assessed via flow cytometry for macrophages, eosinophils, neutrophils, B cells, CD4+ and CD8+ T cells. D Lung cell isolates were stimulated with PMA/ionomycin, and cytokine production assessed via flow cytometry. Data are from 4 independent experiments (n = 33 biologically independent animals). Data were fit to a linear mixed effect model, with experimental day as a random effect variable, and groups with a two-sided Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001. Data are presented as mean values ± SEM. Source data are provided as a Source Data file.

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