Fig. 7: Summary characteristics of PURE-01 consensus expression subtypes.

Top to bottom: cluster number; subtype name; immune class (desert, infiltrated or excluded); GSEA signed areas under the curve (AUCs) for gene sets from Mariathasan et al. 2018²⁰, positive vs. negative AUCs indicate enriched vs. repressed sets and AUC = 0 indicates either that no result was returned from a CERNO⁵² test with qval <0.05, or p_adj > 0.1; GSEA summary, largely from MSigDB Hallmark gene sets; PD-L1 status (CPS > 10% for PD-L1+); response to pembrolizumab treatment (CR, PR, NR); number of samples and percent of the n = 82 cohort; and finally the percent of samples in a subtype that had recurrences within 24 mo.