Fig. 8: GPC1 is involved in Wnt signaling in pancreatic cancer. | Nature Communications

Fig. 8: GPC1 is involved in Wnt signaling in pancreatic cancer.

From: The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Fig. 8

a Western blot analysis of Wnt3a expression in pancreatic cancer cell lines as well as the normal pancreatic duct cell line hTERT-HPNE. b Schematic of the TCF/LEF reporter assay (created with BioRender.com). c Overexpression of GPC1 increased TCF/LEF report activity. n = 3 independent experiments. **p < 0.01, two-tailed unpaired Student’s t test. d D4 CAR T cells inhibited Wnt signaling in T3M4 cells. Values represent mean ± SEM. Source data and exact p values are provided in the Source data file.

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