Fig. 3: MPI library inhibits both bacterial-sized polyP and platelet-sized polyP procoagulant activity in vitro.
From: Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
A–C inhibition of LC polyP by MPI 6—MPI 9. D–F inhibition of LC polyP by MPI 1—MPI 5. G–I inhibition of SC polyP by MPI 6—MPI 9. J–L inhibition of LC polyP by MPI 1—MPI 5. LC polyP assays were performed with 20 µM LC polyP, while SC polyP assays were performed with 8.3 fM TF (tissue factor) and 5 µM SC polyP. Column 1 panels represent thrombin generation curves with a smoothing factor of 2 from 1 biological replicate as a representation. Column 2 panels represent lag times from thrombin generation assays. Column 3 panels represent peak thrombin from thrombin generation assays. Columns 2 and 3 represent mean values +/− SD from n = 3 biologically independent experiments.
