Fig. 5: Protective efficacy against SARS-CoV-2 Omicron BA.1 inoculation after Ad26.COV2.S, Ad26.COV2.S.529, or a combination of Ad26.COV2.S and Ad26.COV2.S.529 late booster in adult rhesus macaques.
Animals were challenged with 1 × 106 PFU Omicron BA.1 SARS-CoV-2 administered intranasally and intratracheally 6 weeks after the booster/immunization. Viral load (sgRNA) overtime from 1 week prior to challenge up to sacrifice (day 13 or 14 post-challenge; indicated as 14 on the graphs) in a BAL and b NS expressed as log10 sgRNA copies/mL (BAL) or log10 sgRNA copies/swab (NS) from 42 NHPs. Viral loads in the individual animals are depicted with gray points and paired measurements connected with gray lines. For all panels, n = 7 animals per group except for the Sham-Ad26.COV2.S.529 group where n = 6 animals and for the Sham-Sham group where n = 8 animals. The median viral load per group is indicated with the red line. The dotted lines indicate the LLOD. Source data are provided as a Source Data file. BAL bronchoalveolar lavage, LLOD lower limit of detection, NHP nonhuman primate, NS nasal swab, PFU plaque-forming units, sgRNA subgenomic RNA.
