Fig. 6: Cutaneous nociceptors serve as essential downstream of TNC in mediating skin inflammation.
From: Tenascin C+ papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis
a Quantification of tail flick time in 52 °C hot water of vehicle (Vec, n = 7) or resiniferatoxin (RTX, n = 9)-treated Tncfl/fl and Col1a2CreERTncfl/fl mice. Representative H&E staining images (b) and quantification (c) of skin acanthosis of untreated (UT)/IMQ-induced Tncfl/fl or Col1a2CreERTncfl/fl mice treated with Vec or RTX (n = 2–3 per group). FLOX, Tncfl/fl; cKO, Col1a2CreERTncfl/fl. Scale bar in (b), 100 μm. Flow cytometric analysis (d) and quantification (e) of conventional T-cell and γδT cells in skin lesions of IMQ-induced Tncfl/fl or Col1a2CreERTncfl/fl mice treated with Vec or RTX (n = 2–3 per group). Flow cytometric analysis (f) and quantification (g) of IL-17A expression in T cells in psoriasiform skin lesions of Tncfl/fl or Col1a2CreERTncfl/fl mice treated with Vec or RTX (n = 3 per group). Data are representatives of two independent experiments and presented as mean ± SEM. The P values were calculated by two-tailed unpaired Student’s t-test (a), two-way ANOVA and Holm–Šídák test (c, e) and one-way ANOVA and Tukey’s test (g). Source data are provided as a Source Data file.
