Table 2 Cox hazard ratios (HRs) for recurrence in FinXX samples

Protein	Intraepithelial univariable HR (95% CI)	p-value	Stroma univariable HR (95% CI)	p-value	Intraepithelial multivariable HR (95% CI)	p-value	Stroma multivariable HR (95% CI)	p-value
B2M	0.458 (0.169, 1.244)	0.116	0.338 (0.114, 1.000)	0.040	0.532 (0.194, 1.456)	0.219	0.415 (0.138, 1.247)	0.117
CD11c	0.321 (0.109, 0.951)	0.031	0.787 (0.321, 1.932)	0.601	0.402 (0.133, 1.212)	0.106	1.395 (0.544, 3.578)	0.488
CD20	0.318 (0.108, 0.942)	0.029	0.817 (0.333, 2.005)	0.658	0.283 (0.095, 0.839)	0.023	0.718 (0.292, 1.768)	0.471
CD40	0.210 (0.062, 0.713)	0.006	0.321 (0.109, 0.951)	0.031	0.278 (0.081, 0.953)	0.042	0.570 (0.179, 1.817)	0.342
CD56	0.209 (0.062, 0.710)	0.006	0.452 (0.166, 1.226)	0.109	0.206 (0.061, 0.701)	0.011	0.473 (0.174, 1.285)	0.142
GZMB	0.430 (0.158, 1.167)	0.088	0.465 (0.171, 1.261)	0.123	0.179 (0.062, 0.517)	0.001	0.168 (0.058, 0.490)	0.001
HLA-DR	0.204 (0.060, 0.695)	0.005	1.488 (0.634, 3.490)	0.358	0.263 (0.077, 0.905)	0.034	1.628 (0.692, 3.829)	0.264
ICOS	0.208 (0.061, 0.704)	0.005	0.644 (0.252, 1.646)	0.354	0.229 (0.067, 0.779)	0.018	0.836 (0.321, 2.176)	0.713
IDO1	0.224 (0.066, 0.759)	0.009	0.224 (0.066, 0.759)	0.009	0.358 (0.099, 1.292)	0.117	0.439 (0.092, 2.093)	0.302
PD-L1	0.610 (0.239, 1.560)	0.297	0.821 (0.334, 2.014)	0.666	0.530 (0.206, 1.359)	0.186	0.936 (0.379, 2.314)	0.886
PD-L2	0.914 (0.373, 2.243)	0.845	0.691 (0.270, 1.766)	0.437	0.660 (0.266, 1.637)	0.370	0.561 (0.218, 1.442)	0.230

HRs were calculated using protein abundance (All Intraepithelial or All Stroma, as defined in the legend in Table 1) and time to event as continuous variables. Univariable and multivariable (adjusted for sTILs) HRs and p-values for 11 proteins (10 differentially expressed at BYadj p < 0.05 plus PD-L1). Bold font indicates two-sided p < 0.05. p-values were adjusted for stromal tumor-infiltrating lymphocytes (sTILs). Source data are given in Supplementary Table 2.

Quick links

Search