Fig. 5: Annotation of AlphaFold2 structures.
From: Metal3D: a general deep learning framework for accurate metal ion location prediction in proteins
a Predicted metal binding sites (a, b) from Metal3D, respectively AlphaFill compared to the experimentally found zinc positions for Uniprot O95630. Metal3D places the metal with high accuracy even if sidechains are not perfectly predicted by AlphaFold for site 1. b Palmitoyltransferase ZDHHC23 (Uniprot Q8IYP9) and ZDHHC15 (Uniprot Q96MV8). AlphaFill can only place the metal for ZDHHC15 because sequence identity for ZDHHC23 is only 24%. Probability isosurfaces from Metal3D for both structures at p = 0.6, colored in gray.
