Table 2 Fixed parameter values used in our simulations

From: In silico cancer immunotherapy trials uncover the consequences of therapy-specific response patterns for clinical trial design and outcome

Parameter

ρ

δ

ξ

g

hT

αA

hI

mS

pS

αN

αe

δA

pI

β

ϵ

M1

5

0.019

0.001

10000000

571

 

571

1

1

0.0025

     

M2

0.045

0.178

0.00000134

92330

60095000

2073.5

    

0.8318

0.231

   

M3

0.045

0.019

0.0000000001

10000000

 

2073.5

      

0.05

1.1 ⋅ 1012

10−12

  1. All values except ρ are taken from previous work, and are kept constant in all simulations. The value of ρ is allowed to vary between simulated patients to account for heterogeneity, and the distribution of ρ is fitted to real data. The values of ρ shown here were those used to generate Fig. 2.
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