Fig. 2: Avalanche scaling of χ = 2 for ongoing neuronal synchronization is robust to numerous experimental conditions.
From: Parabolic avalanche scaling in the synchronization of cortical cell assemblies
a–d Ongoing activity in mPFC/ACC using GCaMP7s exhibits parabolic avalanches in the subset of synchronized neurons. a χsh ≅ 2 is identifiable in the subpopulation of synchronized neurons for k = 16 (data pooled from n = 3 mice over 27 recordings). b Corresponding value of χsh (thick line) and χlg (thin line) as a function of k for all (red) and synchronized neurons only (black). SD from n = 10 bootstrapping repeats. c Corresponding scaling with χsh ≅ 2 for avalanches of duration ~0.3–1.8 s (Φ) at k = 16. d Addition of random spikes, which mimics the presence of noisy, non-synchronized neuronal activity degrades the capacity to recover χsh ≅ 2 (GCaMP7s). Black: see (b); mean ± SD over 10 surrogate sets per condition. e–h Ongoing activity in somatosensory cortex measured with transgenic mice intrinsically expressing GCaMP6s imaged using a mesoscope. e Overview of mesoscopic imaging of large brain area. Note expression of GECIs obscured by large blood vessels. Broken line: midline. FoV: field of view (orange square). f High-resolution image of the FoV in (e) and corresponding period of spontaneous fluctuations in relative fluorescence (red; au) and spikes (black) in a single neuron (red circle). g Scaling regime of χsh increases with FoV. For a large FoV, χsh ≅ 2 holds over for avalanches of duration 0.1–5 s (Φ) at k = 1–2 (n = 2 mice from 2 recordings). h Corresponding average value of χsh and χlg as a function of k (soft thresholding; mean ± SD). Black dashed lines: Guide to the eye.
