Fig. 2: Overview of genome-wide binding correlation and DNA sequence motifs of C/S1 bZIP dimers.
From: Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors
a S1 (labeled in orange color) and C (labeled in teal color) bZIPs are co-expressed in multiple Arabidopsis tissues at different developmental stages. b Hierarchical clustering using the Pearson correlation matrix of genome-wide binding profiles revealed three major clusters for C/S1 dimers (Cluster C1, C2, C3) that were separated from representative bZIPs from other groups, TGA5 (group D) in Cluster C4 and bZIP18 (group I) in Cluster C5. Pearson correlations were computed using log2-transformed normalized read counts on a consensus peak set of 8505 peaks where each peak is in the top 3000 most enriched peaks in each replicate (see “Methods” section). No statistical tests were used. c PWM models of the most enriched (primary) and the second most enriched (secondary) motifs discovered from the 1000 strongest bound peaks for each C/S1 bZIP homodimer and heterodimer. Cluster memberships correspond to those from b.
