Fig. 6: Cell-cell interaction analysis between the different lung cell populations after different time points and doses of IR.
From: An interactive murine single-cell atlas of the lung responses to radiation injury
a Circle plot showing the differential number of interactions between IR10Gy and IR17Gy in the main cellular compartments at 3 M, 4 M, and 5 M post-IR: mesenchymal, endothelial, epithelia, myeloid and lymphoid. Red (or blue) colored edges represent increased (or decreased) signaling in the IR17Gy compared to the IR10Gy. b Heatmap showing the differential number of interactions between IR10Gy and IR17Gy in the endothelial and mesenchymal subpopulations at 3 M, 4 M, and 5 M post-IR. Red (or blue) represents increased (or decreased) signaling in the IR17Gy compared to the IR10Gy. The top-colored bar plot represents the sum of column of values displayed in the heatmap (incoming signaling). The right-colored bar plot represents the sum of row of values (outgoing signaling). c Bar graph showing significant signaling pathways ranked based on differences in the overall information flow within the inferred networks between IR5M10Gy and IR5M17Gy from the Fibroblasts Col14a1 and Myofibroblasts (sources) to the gCap (targets). The top signaling pathways colored red are enriched after IR5M10Gy, and the ones colored green were enriched after IR5M17Gy. d Increased signaling ligand-receptor pairs of the Collagen pathway in IR10Gy and IR17Gy compared to NI at 3 M, 4 M, and 5 M after IR. e Schematic drawing of the intercellular communication between fibroblasts and myofibroblasts with the gCap through the collagen pathway.
