Fig. 5: Comparison between GGBE variants and AGBE in HEK293T cells.
From: HMGN1 enhances CRISPR-directed dual-function A-to-G and C-to-G base editing
a Schematic of base editor variant of GGBE1.0, GGBE1.3, and mini-AGBE4. b The genotypes and reads and editing frequency of indicated genotypes across GGBE1.0, GGBE1.3, and mini-AGBE4 at VISTA, RP11-site1, and HEK4. c Comparison of editing efficiency across GGBE1.0, GGBE1.3 and mini-AGBE4 in HEK293T cells. d Comparison of editing proportion of C-to-A/T/G across GGBE1.0, GGBE1.3 and mini-AGBE4 in HEK293T cells. e Comparison of indel frequency across GGBE1.0, GGBE1.3 and mini-AGBE4 in HEK293T cells. Mean ± SEM (c–e) of all individual values of sets of n = 3 independent replicates are shown. All statistical analyses for samples were conducted using unpaired Student’s t test (two-tailed) in GraphPad Prism 8. Source data are provided as a Source Data file.
