Table 1 The effect of 2H on the growth and viability of various yeast strains/isolates

From: A first-in-class inhibitor of Hsp110 molecular chaperones of pathogenic fungi

Yeast strains/isolates

MIC90−2H

MFC-2H

MIC90-FLC

C. albicans SC5314

25

25

6.4

C. albicans SC5314 + sorbitol

25

25

N/A

C. albicans JS14

25

25

500

C. albicans JS15

25

25

>500

C. albicans FH5

12.5

25

125

C. albicans 12-99

25

25

>500

C. glabrata 2001

25

25

500

S. cerevisiae BY4742MSI3 sse1Δ

15

20

N/A

  1. The MIC90 (MIC90 −2H) and MFC (MFC-2H) of 2H were determined on several yeast strains/isolates. Fluconazole (MIC90-FLC) was used as a control. MIC90: the minimum inhibitory concentration for 90% inhibition. The minimal fungicidal concentration (MFC): the minimal concentration of the drug resulting in less than 0.1% of the cells alive relative to the original inoculum. N/A not determined.
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