Fig. 2: Differentially expressed circRNAs between non-response and response patients and circRNA-miRNA-mRNA axes. | Nature Communications

Fig. 2: Differentially expressed circRNAs between non-response and response patients and circRNA-miRNA-mRNA axes.

From: Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy

Fig. 2

Volcano plot of upregulated (red) and downregulated (blue) circRNAs between non-response and response melanoma samples in pre-treatment (PRE; a) and early during therapy (EDT; b) samples, respectively (P < 0.05, |log2 (fold change)| ≥0.5; See Methods). c The overlap of upregulated circRNAs identified in PRE (a) and EDT (b) samples (81 shared circRNAs with 80 in MiOncoCirc and 74 host genes). d Strategy of ICB associated circRNA-miRNA-mRNA axes (upper panel, see method), and the network of all circRNA-miRNA-mRNA interaction pairs (bottom panel). “+” represent the positive correlation between the expression of circRNAs and mRNAs. e Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and GO biological process analysis among the mRNAs identified in ICB-associated circRNA-miRNA-mRNA axes (P < 0.05). The statistical analysis was performed by a two-sided linear mixed-effects model (LME) in a, b and two-sided Fisher’s test in e. PRE pre-treatment, EDT early during therapy. Source data are provided as a Source data Fig. 2.

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