Fig. 5: Comparisons of ICBcircSig score model and other transcriptome-based signatures of ICB. | Nature Communications

Fig. 5: Comparisons of ICBcircSig score model and other transcriptome-based signatures of ICB.

From: Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy

Fig. 5

a Performance of ICBcircSig score and other published signatures based on ROC curves quantifying ICBcircSig score response prediction AUC in each cohort. b AUC of time-dependent ROC of 6, 12, and 18-months for each cohort. c HR for FPS in each cohort. The statistical difference is performed by cox regression model. Red dashed line indicated p value 0.05. d P value of two-sided Wilcoxon rank-sum test (left panel) and logistic regression test (right panel) between response versus non-response, red dashed line indicated p value 0.05. Blue point means 6 months, red point means 12 months and green point means 18-months in b (n = 3). The boxes in b indicate the median ± 1 quartile, with the whiskers extending from the hinge to the smallest or largest value within 1.5× IQR from the box boundaries. ROC receiver operating characteristic curve, HR hazard ratio, AUC Area Under the ROC Curve. Source data are provided as a Source data Fig. 5.

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