Fig. 4: Comparison of genomic mutagenesis between sporadic cancers, XP-E and XP-C groups.

a Multidimensional scaling (MDS) plot based on the Cosine similarity distance between the SBS trinucleotide-context mutation profiles of the samples (Dimensions 1 and 2—left panel, Dimensions 1 and 3—right panel). Colors encode groups of the samples and shapes encode types of cancers. n = 31 for SCC, n = 8 for BCC, n = 113 for MEL, n = 10 for XP-E and n = 8 for XP-C (tumors). b PCA plot based on the density of mutations in 2684 1Mb-long windows along the genome (only for samples with more than 50k mutations belong to sporadic, XP-C and XP-E groups). Colors encode groups of the samples and shapes encode types of cancers. n = 4 for BCC, n = 83 for MEL, n = 26 for SCC, n = 8 for XP-C and n = 10 for XP-E (tumors). c The transcriptional bias (TRB; ratio between untranscribed and transcribed strand mutation number) for C > T mutations from pyrimidine dimers in genes grouped in 6 bins by gene expression level. Only cutaneous SCC tumors were used for XP-C and XP-E groups. Data are presented as mean values +/− SEM. n = 31 for SCC, n = 5 for XP-C and n = 7 for XP-E (tumors). Source data are provided as a Source Data file. d Fractions of C > T mutations from pyrimidine dimers separated by strands in the TSS-centered 100 kb region (binned by 10 kb intervals). Blue line—untranscribed strand for purines or transcribed for pyrimidines, red line—transcribed strand for purines or untranscribed for pyrimidines. Data are presented as mean values +/− SEM. n = 31 for SCC, n = 5 for XP-C and n = 7 for XP-E (tumors). Source data are provided as a Source Data file.