Fig. 7: Protein-damaging effect of mutation contexts.
From: Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients
a Correlations between tumor mutation burden and number of oncogenic and likely oncogenic mutations in the studied skin cancer samples according to the OncoKB database. Pearson’s r coefficients and P values are indicated. b Mean fraction of exonic mutations from all the mutations per sample. Data are presented as mean values +/− SEM. n = 31 for SCC, n = 8 for BCC, n = 113 for MEL, n = 10 for XP-E, n = 8 for XP-C, n = 3 for XP-A, n = 3 for XP-D and n = 14 for XP-V (tumors). Source data are provided as a Source Data file. c Protein-damaging/silent mutation ratio per substitution type in our pooled skin cancer cohort (n = 190 tumors). Damaging mutations—all non-silent exonic (missense, truncating) and splice site mutations. Boxes depict the interquartile range (25–75% percentile), lines—the median, whiskers—1.5× the IQR below the first quartile and above the third quartile. d Mean fraction of protein-damaging mutations originating from the main mutation classes split by gene strand per group.
