Fig. 6: Interactions between DBLMSP family proteins and Fcμ.
From: Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M
a Interactions between DBLMSPDBL SD1 and Fcμ. DBLMSP residues that are mutated in DBLMSP-M1 are highlighted with red boxes. b Interactions between DBLMSPDBL SD2 and Fcμ. DBLMSP residues that are mutated in DBLMSP-M2 are highlighted in red boxes. c Interactions between DBLMSPDBL SD3 and Fcμ. d DBLMSPDBL mutants display reduced binding to Fcμ–J. All pull-down experiments have been repeated three times with similar results. e DBLMSP2DBL form extensive interactions with Glu525–Glu527 in Cμ4Fcμ1B. f DBLMSP2DBL interacts with Glu525–Glu526 in Cμ4Fcμ2B.
