Fig. 7: The binding sites of VAR2CSA, TM284VAR1, DBLMSP, and DBLMSP2 on Fcμ–J overlap with that of pIgR/SC and the high-affinity site of FcμR. | Nature Communications

Fig. 7: The binding sites of VAR2CSA, TM284VAR1, DBLMSP, and DBLMSP2 on Fcμ–J overlap with that of pIgR/SC and the high-affinity site of FcμR.

From: Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

Fig. 7

The structures of Fcμ–J in complexes with the D1 domain of pIgR/SC (purple), FcμR (R1 site, green)44, VAR2CSADBL3X–DBL5ε, TM284VAR1DBL4ζ, DBLMSPDBL, and DBLMSPDBL are shown in the same orientation for comparison. Fcμ–J and the DBL domains are colored as in Fig. 2. Only the Cμ4 domains of Fcμ are depicted for clarity.

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