Fig. 1: Cryo-EM structure of TRPM7 in the apo state.
From: Structural mechanisms of TRPM7 activation and inhibition
a Cryo-EM density map of TRPM7 in the closed, apo state at 2.19 Å resolution, viewed parallel to the membrane (left) and extracellularly (right). One of the four subunits is colored green, and the other three in grey. Lipid densities are highlighted in brown. The semi-transparent surface represents the lipid nanodisc density. b Close-up view of a map region in the TMD. c Structural model of TRPM7Closed reconstituted in lipid nanodiscs. One of the four subunits is colored in green, and the other three in grey. Lipids are shown as brown sticks. d Representative cryo-EM density (blue mesh) and models (brown sticks) for cholesterol and phospholipid.
