Fig. 5: The clustered regularly interspaced short palindromic repeat (CRISPR)–CRISPR-associated protein (Cas) systems and the predicted anti-CRISPR (Acr) proteins in the built environment viromes. | Nature Communications

Fig. 5: The clustered regularly interspaced short palindromic repeat (CRISPR)–CRISPR-associated protein (Cas) systems and the predicted anti-CRISPR (Acr) proteins in the built environment viromes.

From: Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution

Fig. 5

a The complete CRISPR/Cas systems identified in two proviruses. The CRISPR locus is highlighted in red. b The potential Acr mechanism found in a virus that could be linked to a host using spacer matching is highlighted by a red dashed box. The Acr protein is indicated by a star, and the CRISPR locus is highlighted in red. c A maximum-likelihood phylogenetic tree of the 162 Acr proteins identified in this study and the 339 Acr proteins obtained from the curated PaCRISPR database48. The branches of the nine novel predicted Acr proteins are shown in red. The red stars on the outer ring denote the predicted Acr proteins with high-confidence structures (plDDT > 80) based on the AlphaFold2 tool. d Comparison of the high-confidence structures (plDDT > 80) of the four novel predicted Acr proteins with their closest reference.

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