Fig. 7: Effect of C115Y on the binding of IL23-TMR and P630-TMR. | Nature Communications

Fig. 7: Effect of C115Y on the binding of IL23-TMR and P630-TMR.

From: Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes

Fig. 7

BRET ratio generated when increasing concentrations of (a) IL23-TMR or (b) P630-TMR were applied to cells expressing wildtype (pink) or C115Y (black) mutant receptor. Data are mean ± SEM from five (C115Y) or four (wildtype) independent experiments conducted in duplicate or triplicate. Details on absolute number of data points included for each concentration are provided in the associated Source Data file.

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