Fig. 7: Structure-based model of the mechanisms underlying HTNV-L replication.
Mechanistic model based on the structures. For the apo, the 5′vRNA-bound and the pre-initiation state, structures are used. For the early- and late elongation states, the elongation structure is used and only the RNA that we propose to be present in each state are shown. The 5′vRNA1–25 (or the mutated 5′vRNA) and 3′vRNA1–25 are respectively colored in pink and yellow and shown as surface. HTNV-L structures are displayed as cartoon with the fingertips in blue, the motif E in magenta, the putative prime-and-realign (PR) loop in orange, the putative priming loop in dark red, the upper jaw in light pink, and in lower jaw in pink. In the pre-initiation state, the position +1 and −4 of the active site are indicated.
