Fig. 2: ERα binds in the proximity of genes that coordinate Kiss1-neuron pulsatility in the arcuate nucleus. | Nature Communications

Fig. 2: ERα binds in the proximity of genes that coordinate Kiss1-neuron pulsatility in the arcuate nucleus.

From: Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice

Fig. 2

A Genes found in proximity to ERα binding sites and affected by estrogen in the arcuate nucleus. B Expression of Kiss1, Kor, Pdyn, and Tac2 genes in the arcuate and AVPVKiss1 nuclei upon E2 treatment. C Expression of Kiss1 and Golt1a in the arcuate and AVPVKiss1 (n = 3-6). Error bars represent SEM. DeseqFDR **p < 0.01, ***p < 0.001, ns not significant. D ERα occupancy at the Golt1a/Kiss1 locus in the arcuate and AVPV nuclei (http://genome-euro.ucsc.edu/). E ERE sequence detected for the Greb1 (positive control), and the peaks identified proximal to Kiss1, Pdyn, and Tac2. Gene expression data were obtained from previously published studies17,118.

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