Table 1 Ligand effect on the enantioselective formal reductive alkyl-alkyl cross-coupling reaction^a

DME dimethoxyethane, DMA dimethylacetamide.
^aThe reaction was conducted using 1a (0.2 mmol), 2a (0.6 mmol) under indicated conditions for 24 h. Yield was determined by GC using n-dodecane as internal standard. The enantiomeric excess was determined by HPLC using a chiral column with stationary chiral phase.
^bReaction conditions: The reaction was run using 1a (0.2 mmol), 2a (0.6 mmol) with NiCl2‧DME (8 mol%), L20 (8 mol%), FeCl2 (25 mol%), Zn (2.0 equiv), CsI (3.0 equiv), 15-crown-5 (10 mol%) in DMA/diglyme = 1:3 (0.1 M) at room temperature for 24 h.
^cIsolated yield after flash chromatography.

Quick links

Search