Fig. 3: Structural and sequence features of RhGB01-like sarbecoviruses. | Nature Communications

Fig. 3: Structural and sequence features of RhGB01-like sarbecoviruses.

From: Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Fig. 3

a The solved RBD structures of SARS-CoV-2, RaTG13, BANAL-236 (close relative of BANAL-20-528) and the AlphaFold2-predicted structure of RhGB07 were superposed. b The 3D surfaces of the RBD-hACE2 binding interface for SARS-CoV-2 and RhGB07. Alignment of sarbecovirus spike proteins showing the conservation of key contact residues involved interactions between (c) SARS-CoV spike and (d) SARS-CoV-2 spike with hACE2. The sequences shown in the alignments are from Asian, European and African sarbecoviruses that have been shown to bind hACE242,43,44. These sequences were ordered based on their genetic relatedness, as inferred from a consensus maximum-likelihood phylogenetic tree reconstructed from their whole genomes (bottom left).

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