Fig. 8: Gene expression profile associated with glial signaling in humanized mice developing neurotoxicity and treated with emapalumab. | Nature Communications

Fig. 8: Gene expression profile associated with glial signaling in humanized mice developing neurotoxicity and treated with emapalumab.

From: Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies

Fig. 8

a Volcano plot of the 33 significantly deregulated genes (32 downregulated and one upregulated) in brain tissue sections of mice developing toxicity after CAR-T cell infusion treated with emapalumab or not. The log2FC indicates the mean expression level for each gene. Genes with negative log2FC are downregulated in mice receiving emapalumab. b STRING tool has been applied to deconvolute the potential interaction network among the 32 genes downregulated in brain tissue sections of mice treated with emapalumab, compared to brain tissues from control mice that did not receive the drug. c Gene enrichment analysis performed through the Enrichr web tool displays the pathways in which the 32 genes downregulated in emapalumab-treated mice are involved. For differential expression analysis, a p value of ≤0.05 (calculated with the nSolver™ 4.0 analysis software), was applied as cutoff. Source data are provided as a Source Data file.

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