Table 1 Enthalpic and entropic contributions of binding by each ligand and their respective affinity, as determined by ITC

From: Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

Compound

n (binding stoichiometry)

∆H (kcal/mol)

T∆S (kcal/mol)

KD (nM)

1

0.747

−13

−5.4

5200

2

1.03

−9.4

−1.7

2300

3

1.27

−7.9

2.5

23

4

1.39

−5.5

4.8

31

5

1.52

−5.4

5.1

18

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