Fig. 2: Pd-catalyzed regiodivergent hydrochlorocarbonylation of aryl alkenes. | Nature Communications

Fig. 2: Pd-catalyzed regiodivergent hydrochlorocarbonylation of aryl alkenes.

From: Palladium-catalyzed regiodivergent hydrochlorocarbonylation of alkenes for formation of acid chlorides

Fig. 2

aConditions: alkene (0.2 mmol), Pd(PtBu3)2 (5 mol%), Ph2tBuSiCl (0.3 mmol), AcOH (0.3 mmol), CO (30 atm), DCE (1.5 mL), 80 °C, 24 h. bConditions: alkene (0.2 mmol), PdCl2 (5 mol%), Xantphos (6 mol%), Ph2tBuSiCl (0.3 mmol), AcOH (0.3 mmol), CO (40 atm), PhCl (1.5 mL), 100 °C, 24 h. c100 °C. Yields refer to isolated yields of the derivatized methyl carboxylates (see SI). The ratios of regioisomers within parentheses were determined by GC-MS analysis of their derivatized methyl carboxylates of crude acid chlorides.

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