Fig. 4: Synthetic application of hydrochlorocarbonylation. | Nature Communications

Fig. 4: Synthetic application of hydrochlorocarbonylation.

From: Palladium-catalyzed regiodivergent hydrochlorocarbonylation of alkenes for formation of acid chlorides

Fig. 4

Conditions for a, b, left column: alkene (0.2 mmol), Pd(PtBu3)2 (5 mol%), Ph2tBuSiCl (0.3 mmol), AcOH (0.3 mmol), CO (30 atm), DCE (1.5 mL), 80 °C, 24 h. Conditions for a, b, right column and c: alkene (0.2 mmol), PdCl2 (5 mol%), Xantphos (6 mol%), Ph2tBuSiCl (0.3 mmol), AcOH (0.3 mmol), CO (40 atm), PhCl (1.5 mL), 100 °C, 24 h. After completed the hydrochlorocarbonylation, the crude acid chloride was involved in follow-up acylation with the corresponding nucleophiles in one-pot. Isolated yields.

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