Fig. 2: Novel replicated variant-metabolite pairs colocalizing for the association with gene eQTLs.

The direction of the effect of minor allele on metabolite levels and gene expression is shown in the legend. At the bottom of the graph, in light gray, are the names of the metabolites. Above the names of metabolites are eQTL gene-tissue pairs. If both the effect of minor allele on metabolite levels and on gene expression is more than 0, such variant-metabolite-gene eQTL combinations are marked in yellow, and annotated as “Same Direction: Positive”. If the effect of minor allele on metabolite levels and on gene expression is less than zero, such variant-metabolite-gene eQTL combinations are marked in purple, and annotated as “Same Direction: Negative”. If the effect of minor allele on metabolite levels is less than zero and the effect of minor allele on gene expression is more than zero, or vice versa, such variant-metabolite-eQTL combinations are marked in gray, and annotated as “Opposite Direction”. Additionally, the following acronyms were used for tissues: BPBG brain putamen basal ganglia, BCH brain cerebellar hemisphere, EBV-TL - Cells EBV-transformed lymphocytes.