Fig. 2: Exogenous NOTCH4ΔL12_16 transfection sensitizes LUAD to EGFR-TKIs. | Nature Communications

Fig. 2: Exogenous NOTCH4ΔL12_16 transfection sensitizes LUAD to EGFR-TKIs.

From: NOTCH4ΔL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1

Fig. 2

a The diagram of NOTCH4 plasmids transfection into PC-9GR/PC-9OR. b, c The ratio of mutation after NOTCH4 plasmids transfection into PC-9GR/PC-9OR or tumor cells of PDX-GR/PDX-OR compared with wild type. The data shown are representative of at least 3 independent repeats. (n = 3 PDXs). d and g The cell viability after NOTCH4 plasmids transfection into PC-9GR/PC-9OR (n = 3 biologically independent experiments). e and h The tumor growth curves of CDX models. (n = 5 CDXs). f and i Tumor weight of CDX models. (n = 5 CDXs). (j, l) The tumor growth curve of PDX models. (n = 6 PDXs). k and m Tumor weight of PDX models. (n = 6 PDXs) mean ± SD. An unpaired two-sided student t-test was performed in Figs. 2b–m. CDX, cell-derived xenograft; PDX, patient-derived xenograft. Source data are provided as a Source Data file.

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