Fig. 6: Substrate scope for asymmetric C-H alkylation. | Nature Communications

Fig. 6: Substrate scope for asymmetric C-H alkylation.

From: Data-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis

Fig. 6

a Scope of indoles. b Scope of alkenes. Reaction conditions: 1 (0.1 mmol), 2 (0.3 mmol), Cp*Co(CO)I2 (10 mol%), AgSbF6 (20 mol%), and CCA-4 (20 mol%) in 1,2-DCE (0.5 mL) at 25 °C for 72 h under N2. Unless noted, the ratio of b:l is >95:5. Yields are those of the isolated products. The diastereomeric ratio (d.r.) were determined by 1H NMR spectroscopy. The enantiomeric excess (e.e.) was determined by HPLC.

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