Fig. 3: Copy number alterations in OAC genomes.

a The upper colour bars represent from top to bottom: overall stage, allocated treatment, PET response and tumour cellularity. The histogram is the overall patient survival, white indicates patients who are alive and black who are dead. The ploidy is shown for each sample. The percentage of copy number alterations across each genome and the percentage of sub-clonal CNA are shown. Samples are grouped into those that contained complex genome events (black, n = 54) and those that did not (white, n = 35), and sorted by overall survival in descending order. There are 89 biologically independent samples. b Kaplan–Meier plot (log-rank test) of patient overall survival for tumours without complex events (n = 35) stratified as ploidy high (upper tertile, n = 11) or low (lower tertile, n = 12). c Kaplan–Meier plot (log-rank test) of patient overall survival for tumours with complex events (n = 54) stratified as ploidy high (upper tertile, n = 18) or low (lower tertile, n = 18). PET, positron emission tomography; CF, Cisplatin and 5-Fluorouracil; DCF, CF and docetaxel; RT, 45 Gy radiotherapy; CNA, copy number alteration. Source data are provided as a Source data file.