Fig. 3: Hyperglycemia enhances fatty acid accumulation in pancreatic tumors.
From: Increased glucose availability sensitizes pancreatic cancer to chemotherapy
a, Peripheral glucose levels in C57BL/6 J mice receiving D30 water or normal water (n = 5 mice per group). b–d, Relative abundance of glucose (b, n = 5 mice per group), other metabolites (c, n = 6 orthotopic tumors per group), and enriched pathways derived from metabolomic analyses (d, n = 6 orthotopic tumors per group) in murine KPC orthotopic tumors after D30 water consumption, as compared to tumors in normoglycemic mice consuming regular water for 14 days. e–g, Principal component analysis (e) and volcano plot (f) derived from transcriptomic analyses, and GSEA of genes associated with fatty acid synthesis (g) in KPC orthotopic tumors under the indicated conditions (n = 5 orthotopic tumors per group). FDR-adjusted p value (q values) are provided. Data are provided as mean ± s.d. (a, b) or mean ± s.e.m. (c). Pairwise comparisons were conducted using two-tailed, unpaired Student’s t-tests. Source data are provided as a Source Data file.
