Fig. 2: Hypotheses regarding possible signaling mechanisms in contralateral kidney triggered by unilateral nephrectomy.
From: Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics
These hypotheses summarize signaling pathways known to mediate responses to mechanical or metabolic signals likely to be triggered by loss of one kidney. (See also Supplementary DiscussionĀ 1 and Supplementary DataĀ 4). UNx unilateral nephrectomy, GFR glomerular filtration rate, ECF extracellular fluid, Ca calcium, CaM calmodulin, TGF transforming growth factor, OCLN occludin.
