Fig. 2: HiAlc Kpn-fed mice and fecal microbiota transplantation (FMT) following phage pretreatment in vitro. | Nature Communications

Fig. 2: HiAlc Kpn-fed mice and fecal microbiota transplantation (FMT) following phage pretreatment in vitro.

From: Bacteriophage targeting microbiota alleviates non-alcoholic fatty liver disease induced by high alcohol-producing Klebsiella pneumoniae

Fig. 2

a Constructions of experimental mice fed with Pair, EtOH, HK1, HK1/phiW14 and HK1/phikp15. b Constructions of FMT and FMT/phage murine models. c Compositions of phylum-based intestinal microbiota in feces of experimental mice. d Abundance of Klebsiella in feces of experimental mice (n = 6, P < 0.0001). e Hematoxylin–eosin (HE) and Oil Red O (ORO) stainings of sections of liver tissues of experimental mice. f Concentrations of alanine transaminase (ALT), aspartate transaminase (AST), triglyceride (TG), diamine oxidase (DAO), and D-lactate (D-LA) in serum of experimental mice (n = 6, except the P value of DAO levels between the group HK1-fed and HK1/ phiW14-fed is 0.001, other P values < 0.0001). Values are expressed as the mean ± SD (n = 6 mice/group). One-way ANOVA, P value < 0.01 (**) or 0.001 (***). Source data are provided as a Source data file.

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