Fig. 2: BNT162b2 elicits significant protective immunity in C57BL/6 J μMT mice.
From: Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response
a Schematic diagram of vaccination, viral challenge, and pathological studies in C57BL/6 J model. b, c The viral loads in the lung and nasal turbinate (NT) of BNT162b2 vaccinated and unvaccinated C57BL/6 J WT/μMT mice at 2 d.p.i. and 4 d.p.i. (n = 6). d, e Representative images of the H&E-stained lung tissues of BNT162b2 vaccinated and unvaccinated C57BL/6 J WT/μMT mice challenged with Alpha (d) or Omicron BA.1 variant (e). Scale bar = 200 μm. Data are presented as mean ± SD. Statistical significance was calculated using one-way ANOVA test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns = not significant). Figure 2a was created with BioRender.com.
