Fig. 3: BNT162b2 stimulates substantially higher levels of cytokines/chemokines in C57BL/6 J μMT mice.
From: Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response
a Schematic diagram of vaccination, viral challenge, and multiplex cytokine/chemokine profiling. b Cytokine/chemokine profiles in blood samples collected from BNT162b2 vaccinated and unvaccinated C57BL/6 J WT/μMT mice at 2 d.p.i. of Alpha variant determined by multiplex profiling (For WT mice, n = 10; μMT mice, n = 12). c Schematic diagram of vaccination, viral challenge, and cytokine/chemokine measurement by q-RTPCR. d–i The IFN-γ, IP-10, and MCP-1 expression was determined by q-RTPCR using RNA samples extracted from lung and NT from BNT162b2 vaccinated and unvaccinated C57BL/6 J WT/μMT mice at 2 d.p.i. and 4 d.p.i. of Alpha (d, f, h) or Omicron BA.1 variant (e, g, i) (n = 6). Data are presented as mean ± SD. Statistical significance was calculated using one-way ANOVA test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns = not significant). Figure 3a, c were created with BioRender.com.
