Table 1 Summary of the single cancer GWAS and cross-population single cancer meta-analysis
Cancer type | Discovery | Replication | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BioBank Japan 1 (BBJ1) Sample size | λGC | h2(SE) | GWAS loci | UK Biobank (UKB) Sample size | λGC | h2(SE) | GWAS loci | New loci | Cross-population |  | BioBank Japan 2 (BBJ2) Sample size | Additional new loci | |||||
Case | Control | Case | Control | λGC | GWAS loci | New loci | Case | Control | |||||||||
Biliary tract | 232 | 150,462 | 1.001 | 0.032 (0.144) | 0 | 525 | 334,343 | 1.001 | 0.119 (0.110) | 0 | 0 | 1.011 | 0 | 0 | 584 | 38,088 | 0 |
Breast | 5,099 | 70,676 | 1.005 | 0.095 (0.009) | 7 | 13,778 | 183,466 | 1.030 | 0.146 (0.007) | 25 | 0 | 1.056 | 33 | 1 | 4,804 | 18,138 | 0 |
Cervical | 567 | 70,676 | 1.003 | 0.110 (0.031) | 1 | 313 | 183,466 | 1.003 | 0.189 (0.102) | 0 | 0 | 1.007 | 1 | 0 | 1,358 | 18,138 | 0 |
Colorectal | 6,075 | 150,462 | 1.020 | 0.140 (0.011) | 14 | 7,194 | 334,343 | 1.022 | 0.174 (0.015) | 10 | 1 | 1.048 | 23 | 0 | 7,382 | 38,088 | 0 |
Endometrial | 948 | 70,676 | 1.010 | 0.081 (0.027) | 0 | 1,892 | 183,466 | 1.009 | 0.062 (0.026) | 1 | 0 | 1.016 | 0 | 0 | 1,012 | 18,138 | 0 |
Esophageal | 1,159 | 150,462 | 0.997 | 0.206 (0.027) | 2 | 1,387 | 334,343 | 1.016 | 0.206 (0.044) | 0 | 0 | 1.005 | 3 | 0 | 1,018 | 38,088 | 0 |
Gastric | 5,775 | 150,462 | 1.021 | 0.095 (0.009) | 4 | 1,023 | 334,343 | 0.999 | 0.013 (0.054) | 0 | 0 | 1.030 | 4 | 0 | 4,324 | 38,088 | 0 |
Hepatocellular | 1,361 | 150,462 | 1.011 | 0.143 (0.036) | 1 | 339 | 334,343 | 0.994 | 0.190 (0.190) | 2 | 0 | 1.009 | 3 | 0 | 2,180 | 38,088 | 1 |
Lung | 3,486 | 150,462 | 1.018 | 0.136 (0.019) | 6 | 4,255 | 334,343 | 1.016 | 0.293 (0.028) | 3 | 0 | 1.029 | 7 | 1 | 3,477 | 38,088 | 0 |
Non-Hodgkin’s lymphoma | 736 | 150,462 | 1.016 | 0.138 (0.046) | 1 | 1,997 | 334,343 | 1.010 | 0.073 (0.014) | 2 | 1 | 1.018 | 5 | 0 | 935 | 38,088 | 0 |
Ovarian | 685 | 70,676 | 1.005 | 0.023 (0.027) | 0 | 1,446 | 183,466 | 1.001 | 0.006 (0.026) | 0 | 0 | 1.009 | 0 | 0 | 835 | 18,138 | 0 |
Pancreatic | 281 | 150,462 | 0.999 | 0.312 (0.156) | 0 | 1,328 | 334,343 | 1.004 | 0.031 (0.051) | 1 | 0 | 1.005 | 1 | 0 | 604 | 38,088 | 0 |
Prostate | 4,626 | 79,786 | 1.024 | 0.202 (0.009) | 20 | 10,739 | 150,877 | 1.021 | 0.172 (0.007) | 39 | 0 | 1.051 | 45 | 0 | 6,036 | 19,950 | 0 |
